Pharmaceutical Hot-Melts Research 관련 자료 입니다;
Overview
Purpose: Provide on the one hand an efficient screening tool for Hot-Melt
Extrusion (HME) formulation development and make available on the other
hand rheological parameters for process development and optimization,
as well as for modeling calculations for compounding and extrusion.
Methods: Rheometry and polarization light microscopy up to 300 °C with
well-defined heating and cooling rates, temperature profiles and shear
rates as well as oscillatory testing.
Results: This combined method requires only a small sample volume and
delivers efficiently significant and well-correlated rheological data and
microscopic images, which allow to investigate formation and stability of
solid solutions or crystalline dispersions. Moreover these results deliver
at the same time meaningful parameters for extruder dimensioning and
processability and for simulation calculations of the pharmaceutical
Pharmaceutical Hot-Melts Research 관련 자료 입니다;
Overview
Purpose: Provide on the one hand an efficient screening tool for Hot-Melt
Extrusion (HME) formulation development and make available on the other
hand rheological parameters for process development and optimization,
as well as for modeling calculations for compounding and extrusion.
Methods: Rheometry and polarization light microscopy up to 300 °C with
well-defined heating and cooling rates, temperature profiles and shear
rates as well as oscillatory testing.
Results: This combined method requires only a small sample volume and
delivers efficiently significant and well-correlated rheological data and
microscopic images, which allow to investigate formation and stability of
solid solutions or crystalline dispersions. Moreover these results deliver
at the same time meaningful parameters for extruder dimensioning and
processability and for simulation calculations of the pharmaceutical